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Finding the cause of Motor Neuron Disease: Project 1
| Florey Neuroscience Institutes |
Co-supervisor: Dr. Brad Turner
The childhood illness called Spinal Muscular Atrophy is caused by mutation is a protein called Survival of motor neurons (SMN). We have several pieces of evidence to suspect that this protein might also be an important contributor to causing Motor Neuron Disease (MND).  View project details
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Finding the cause of Motor Neuron Disease: Project 2
| Florey Neuroscience Institutes |
Co-supervisors: Dr. Brad Turner, Dr. Julie Atkin
Three proteins, SOD1, TDP-43 and FUS are important to the pathogenesis of Motor Neuron Disease (MND). These proteins are secreted normally and this secretion is altered in MND. We believe that this change in secretion is an important clue to the cause of MND. We have found that this secretion is through exosomes. This project is to understand both how it is secreted and why it is disturbed in MND.
View project details
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Finding the cause of Motor Neuron Disease: Project 3
| Florey Neuroscience Institutes |
Co-supervisors: Dr. Brad Turner, Dr. Julie Atkin
We were among the first to show that Endoplasmic Reticulum (ER) Stress was a very early event in the pathogenesis of Motor Neuron Disease (MND). We have evidence that ER stress is caused by the abnormal binding of three proteins (SOD1, TDP-43 and FUS), which are important to the pathogenesis of MND to the motor molecules that transport cargo around the cell. This project will be to try and pin down exactly how this process occurs. View project details
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Finding the cause of Parkinsons disease: Project 1
| Florey Neuroscience Institutes |
Alpha synuclein is generally accepted to be an important molecule in the pathogenesis of Parkinson's Disease (PD). We have found that alpha synuclein is elevated in about half the people with PD. We have also found that alpha synuclein in plasma is made by blood cells and that in people with PD, some blood cells have a shorter life span. This project is to find out whether blood cells are “affected with PD” and can be used to understand how neurones are killed in PD. View project details
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Finding the cause of Parkinsons disease: Project 2
| Florey Neuroscience Institutes |
Alpha synuclein is generally accepted to be an important molecule in the pathogenesis of Parkinson's Disease (PD). We have found that alpha synuclein is elevated in about half the people with PD. We have also found that alpha synuclein in plasma is made by blood cells and that in people with PD, some blood cells have a shorter life span. This project is to find out how alpha synuclein is secreted by blood cells and whether nerve cells secrete it the same way. View project details
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