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The role of P2X7 receptor in endocytosis
| Florey Neuroscience Institutes |
Co-supervisor: Prof. James S. Wiley
Endocytosis is a fundamental biological function of cells. Our group have shown a novel biological role of the P2X7 receptor in phagocytosis of beads, bacteria and apoptotic cells. In this project, we will further investigate the role of P2X7 in endocytosis in monocyte/macrophages as well as transfected HEK-293 cells. This work may help us better understanding of the biological function of the pro-inflammatory P2X7 receptor, which plays a broad role in infection, inflammation and autoimmunity.  View project details
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The role of TAM receptor signalling in central demyelination
| Florey Neuroscience Institutes |
Co-supervisor: Prof Trevor Kilpatrick
Oligodendrocytes are the cells in the central nervous system (CNS) that produce myelin. In diseases such as Mulitple Sclerosis, oligodendrocytes are damaged and myelin lost in a process known as demyelination. The process is influenced by another cell type, the microglia. View project details
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The role of the neurotrophins in promoting myelination
| Florey Neuroscience Institutes |
The neurotrophins are a family of soluble growth factors that support the survival, differentiation and maintenance of several types of neural cells. Recent data have indicated an important role for the neurotrophins in modulating myelination during development and re-myelination following injury. View project details
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The Role of the Unfolded Protein Response in Motor Neuron Disease
This project will investigate how endoplasmic reticulum stress and the unfolded protein response, recently identified by our group as being associated with pathogenesis, relate to neurotoxicity in Motor Neuron Disease. View project details
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Tracking neural precursor cell migration following central demyelination
| Florey Neuroscience Institutes |
Supervisors: Dr Toby Merson, Prof T.J. Kilpatrick
The Multiple Sclerosis Group is focused on developing strategies to limit the severity of demyelinating diseases of the central nervous system, of which multiple sclerosis (MS) is the most common cause. Multiple Sclerosis is thought to result from an autoimmune attack against myelin, which is produced by specialised glial cells known as oligodendrocytes that ensheath neurons. Our research is focused upon reducing oligodendrocytic damage or enhancing nervous system repair by promoting neural precursor cell recruitment to the oligodendrocyte lineage. View project details
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