|
Regenerating dopamine neurones after injury
| Florey Neuroscience Institutes |
Co-supervisors: Dr T Auman, Dr I Gantois
After an injury, we found that dopamine neurones could regenerate and repair the connections to the striatum. This repair involves neurones changing phenotype (to a dopamine neurone), axon extension and sprouting, and synapse formation.  View project details
|
|
|
Regulation of inflammation and cell survival by TAM receptors
| Florey Neuroscience Institutes |
Co-supervisor: Prof Trevor Kilpatrick
In Multiple Sclerosis (MS), oligodendrocytes, the myelin-producing cells of the brain, are damaged and myelin is lost in a process called demyelination. Although the initial cause of MS is unknown, it is known that the development of MS involves interactions between many types of cells, including neurons and the immune system.
View project details
|
|
|
Regulation of skeletal muscle ClC-1 chloride channels; a role in fatigue?
| Florey Neuroscience Institutes |
We have identified a molecular mechanism modulating ClC-1 chloride channels that may be critical in regulating muscle fatigue. This project aims to define this mechanism further and assess its contribution to fatigue. View project details
|
|
|
Regulation of the dopamine phenotype in adult brain cells
| Florey Neuroscience Institutes |
We’re investigating how the excitability or discharge pattern of midbrain dopaminergic neurones regulates their capacity to synthesise dopamine. We believe that intracellular calcium transients lead directly and indirectly to altered patterns of gene expression in these cells, including changes in expression of key proteins underlying the dopamine phenotype. Our experiments are aimed at: (1) testing drugs that alter the excitability of midbrain dopaminergic neurones as potential new therapies for treating Parkinson’s disease; (2) identifying key proteins mediating calcium-induced changes in dopamine gene expression; and (3) defining the relationship between discharge, intracellular calcium transients and dopamine gene expression. View project details
|
|
|
Relation between properties of cerebrospinal fluid and ventricular zone cells in the developing brain
| A/Prof. Kate Dziegielewska |
During development cells lining the ventricles, in the so called ventricular
zone, are the only cells exposed to proteins present in the cerebrospinal
fluid, CSF. View project details
|
|
