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Plasticity in learning and memory
What we hope to learn in our experiments above is which circuits are involved in the learning of a particular event. But to understand the learning process fully, we need to understand what changes occur in learning which result in the storage of that information in memory.  View project details
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Predictors of Impulsive-Compulsive Behaviours (ICBs) during Adolescence
Co-superisor: Prof Nick Allen
It is well known that “compulsive” and “impulsive” behaviours relate to a host of personal and social problems (e.g., excessive eating and internet useage, pathological gambling etc), which are commonly observed in the general population. Despite the prevalence of these problematic behaviours, very little is known about how individual differences in the psychological and biological aspect of self-regulation influence impulsive and compulsive behaviours (ICBs), and lead to a vulnerability to mental health problems. The role of the PhD candidate will be to apply this battery of tests to investigate the neural and psychological bases of these ICBs in a healthy population of nearly 200 adolescents that we have been following since late childhood as a part of a Adolescent Development Study in Melbourne. View project details
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Protein Disulphide Isomerase and cytoplasmic inclusion formation in Amyotrophic Lateral Sclerosis and other Motor Neuron Diseases.
This project will investigate the role of protein disulphide isomerase, an endoplasmic reticulum chaperone, in preventing the formation of the cytoplasmic inclusions that are associated with disease in Amyotrophic Lateral Sclerosis and other Motor Neuron Diseases. View project details
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Proteomic analysis of cytoplasmic inclusions in sporadic ALS
The composition of insoluble cytoplasmic inclusions found in human motor neuron disease will be examined by proteomics. View project details
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Re-building the nigro-striatal pathway in the Parkinsonian brain
| Florey Neuroscience Institutes |
Co-supervisor: Dr. Clare Parish
Motor dysfunction in Parkinson’s disease (PD) occurs as a result of the degeneration of an important part of the brain circuitry underlying normal motor behaviour – the ‘nigro-striatal’ pathway. The goal of this project is to re-instate normal motor function by re-constructing this pathway through a neural grafting procedure. Success in this project will not only be important for development of improved therapy of PD, but will have broad significance for rebuilding the damaged brain.
View project details
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