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Optimisation of functional imaging acquisition and analysis
| Florey Neuroscience Institutes |
Supervisor(s) - Prof. Graeme Jackson, Dr. David Abbott
Functional MRI (fMRI) is now so widely accepted as a research tool to help map and understand the functional behaviour of the human brain, that it is easy to forget that the first human fMRI studies were conducted less than twenty years ago. There are now thousands of published fMRI studies mapping human brain function in health and disease, most driven by clinician neuroscientists successfully applying what are now considered established methods of acquisition and statistical analysis. Too often, however, the methods used are not optimal, nor even appropriate. Recent research in our own laboratory and in others indicates that there is a wealth of information that can be extracted from existing fMRI studies that is currently being ignored. The aim of this project is to systematically investigate a selection of current MRI analysis controversies, develop and evaluate several novel methods of analysis, and investigate brain function and structure using the existing imaging data of healthy individuals and patients.  View project details
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Orbitofrontal cortex gyrification and temperament in early adolescence
| National Neuroscience Facility |
Supervisors:Dr Stephen Wood, A/Prof Nick Allen
This project will examine the relationship between temperament and patterns of sulci and gyri on the orbitofrontal cortex of 150 early adolescents View project details
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Orbitofrontal cortex sulcogyral patterns in early psychosis
Supervisors: Dr Cali Bartholomeusz, A/Prof Stephen Wood
This project aims to classify brain folding patterns of the orbitofrontal cortex, in young people with a psychotic illness. Findings from this project will have implications for identification of a possible vulnerability markers for psychosis. View project details
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Origin and axonal projection of neuron subtypes in the sympathetic nervous system
Understanding how the nervous system generates and then connects the different types of cells it needs during embryonic development is one of the major challenges in biology today. View project details
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Parkinson’s disease: Physiological modulation of alpha synuclein aggregation
Mutations in the α-synuclein gene results in familial autosomal dominant Parkinson's disease (PD). Moreover, α-synuclein is a major component of the intracellular inclusions called Lewy bodies found in PD patient brains further establishing its pathogenic role. View project details
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