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Multichannel neural recording and microstimulation of auditory brainstem: implications for auditory brainstem implant
Supervisor:Associate Professor Tony Paolini
Understanding the complexities underlying brain processing is a crucial step in the development of devices that can artificially drive neural systems.  View project details
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Neural mechanisms that induce hyperthermia and neurodegeneration
| Florey Neuroscience Institutes |
We have recently discovered that nitric oxide synthase and cyclooxygenase enzymes interact in the brain, causing hyperthermia. View project details
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Neuronal networks – wired differently in epilepsy?
| Florey Neuroscience Institutes |
Supervisors: Dr. Verena Wimmer, Dr. Steven Petrou GABA receptors play an important role in mediating inhibitory transmission in the brain. One less well know aspect of GABA receptor signalling is their function in the migration of “young” neurons during embryonic development, when GABA receptors guide the neurons to their appropriate position and allow them to make the correct connections with other cells. Our group has generated a mouse model of human epilepsy which is characterized by a mutation in the GABA receptor subunit gamma2. Our mice show the same epilepsy phenotype human patients have, absence seizures. This project aims at revealing changes in the “wiring” of neuronal networks in the epileptic mouse brain due to GABA receptor dysfunction in development. We will use state-of-the-art laser scanning imaging to visualize synaptic connections and find out how the epilepsy mutation has changed their number, type and specificity. These data will be important for our understanding of how genetic mutations affect different aspects of brain function. View project details
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Neuropathogenic mechanisms of mitochondrial dysfunction
| Murdoch Childrens Research Institute |
Co-supervisors: Dr Ann Frazier
Mitochondrial dysfunction causes a range of early-onset neurological conditions and contributes to neurodegenerative conditions such as Parkinson Disease. The mechanisms of neuronal damage are unknown, and the study of these at a cellular level may lead to improved treatment and greater understanding of the role of both nuclear- and mitochondrial-DNA mutations in both rare and common conditions. Focusing on the most common mitochondrial respiratory chain defect, complex I deficiency, this project will use several cell culture models from both patients and mouse models to study possible mechanisms of neuronal damage. View project details
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Neurophysiology: Ion channel biology and the excitability of neurons
The excitability of neurons is dependent on ion channels, whose correct regulation is essential to normal life. Derangements of ion channels and their control are associated with disordered function, for example in epilepsy and chronic pain. View project details
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