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Manganese Enhanced Magnetic Resonance Imaging

Prof Gary Egan
Florey Neuroscience Institutes

Manganese enhanced magnetic resonance imaging (MEMRI) is a novel neuroimaging technique first introduced by Lin and Koretsky in 1997. In this technique, bivalent manganese ion (Mn2+) is used as a tracer for Ca2+, an important substrate for neurotransmission.

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Mapping connectivity in the healthy and diseased brain

Dr Andrew Zalesky
National Neuroscience Facility

Many psychiatric disorders are now thought to emerge from disruptions in normal brain communication. This project will devise novel computational algorithms to chart a detailed “wiring diagram” of a person’s brain circuitry based on their MRI scan. The algorithm developed will then be put into practice to map whole-brain connectivity in one of several unique populations for which MRI data has already been acquired, including schizophrenics, people afflicted with obsessive compulsive disorder and adolescent inhalant abusers. This will enable us to pinpoint the precise brain circuits that are disrupted at the onset of these conditions. This project is ideally suited to a PhD or Honours student with a strong background in Computer Science, Electrical Engineering, Applied Mathematics or a suitably allied discipline. Previous experience with MRI and other brain imaging modalities is not necessary.

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Measurement of glutamate receptors in Muscarinic Receptor Deficit Schizophrenia

Dr. Simone Boer
Mental Health Research Institute

Supervisors:Dr Simone Boer, Dr Elizabeth Scarr, Assoc Prof Brian Dean

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Measurement of human brain responses to noxious thumbnail pressure stimuli of variable duration

Dr. Michael Farrell
Florey Neuroscience Institutes

Supervisor:Dr Michael Farrell

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Mechanisms controlling body fat in rats

Dr. Richard Weisinger
La Trobe University

Obesity, the excess accumulation of adipose tissue, is a major health problem faced by the current western society.

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