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Investigating inhibitory synaptic function in a mouse model of Autism
Co-supervisor: Prof Terence O’Brien
This project involves the study of altered inhibitory synaptic function in the NL3 mouse model of Autism Spectrum Disorder.
Specifically, the project will investigate:
- electrophysiological characteristics of 2 interneuron subtypes, and
- the effect of the NL3 mutation on endogenous cannabinoid pathways in brain slices.
 View project details
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Investigating molecular and physiological determinants of Sudden Unexplained Death in Epilepsy in acquired and genetic animal models of epilepsy
Co-superviosrs: Dr Jeremy Kennard , Dr Elisa Hill , Prof. Terry O’Brien
This project will investigate the molecular mechanism of Sudden Unexplained Death in Epilepsy View project details
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Investigating neurodevelopmental mechanisms predisposing individuals towards comorbid ADHD, autism spectrum disorders (ASD) and epilepsy
Background: Recurrent seizures, the defining symptom for epilepsy, are frequently observed in both ADHD and ASD patients. Indeed, increased seizure sensitivity may well be inherent to most, if not all, people suffering from ADHD/ASD. Such clinical overlap is currently believed to signify a ‘spectrum of vulnerability’ arising out of an early common dysfunction in central nervous system development. Accordingly natural breeding processes have been used to develop two rat strains; one that is inherently seizure-prone (FAST) and another that is seizure-resistant (SLOW). Alongside the increased seizure sensitivity in FAST rats, several traits naturally evolved that are highly reminiscent of those observed in ADHD/ASD. This project will investigate neurodevelopmental mechanisms that support development of a seizure-prone (FAST) versus seizure-resistant (SLOW) phenotype. View project details
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Investigating the behavioural consequences of ablating adult neurogenesis
| Florey Neuroscience Institutes |
Co-supervisor: Trevor Kilpatrick
The project will investigate the effect upon spatial learning and memory of ablation of neural stem and progenitor cells from the adult mouse View project details
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Investigating the behavioural consequences of ablating adult neurogenesis
| Florey Neuroscience Institutes |
Co-supervisor: Trevor Kilpatrick
The project will investigate the effect upon spatial learning and memory of ablation of neural stem and progenitor cells from the adult mouse View project details
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