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Impulsive-Compulsive Behaviours (ICBs) in Parkinson’s Disease following Dopamine Agonist Therapy
Co-supervisor: Dr Andrew Evans
Growing evidence suggests that ICBs are significantly more prevalent in patients with Parkinson’s disease who are receiving dopamine agonist treatment. Specifically, dopaminergic medication-related disorders such as pathological gambling, hyper-sexuality, and to a minor extent over-eating and shopping have been reported in Parkinson’s disease. While such treatments may have significant implications for the affected individual, the issue has not been comprehensively investigated. One major hurdle has been the clear lack of instruments to measure and characterize ICBs. We have now developed a testing battery that is able index inter-individual variations to ICBs. The role of the PhD candidate will be to apply this battery of tests and conduct neuroimaging to investigate the neural and psychological bases of these ICBs in patients with Parkinson’s disease undergoing dopamine therapy.  View project details
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Impulsive-Compulsive Behaviours (ICBs) in Severe Obesity: Prospective predictors or treatment success/failure following LAP-BAND surgery
Co-supervisor: Dr Melissa Hayden
Growing evidence suggests that ICBs are significantly more prevalent in patients with eating disorders, including severe obesity. While such difficulties may have significant implications for the affected individual (e.g., maintaining maladaptive eating behaviours, and leading to a reduced capacity to take advantage of external resources such as educational opportunities and treatment options), the issue has not been comprehensively investigated. One major hurdle has been the clear lack of instruments to measure and characterize ICBs. We have now developed a testing battery that is able index inter-individual variations to ICBs. The role of the PhD candidate will be to apply this battery of tests to investigate the neural and psychological bases of these ICBs in patients with obesity about to undergo LAP-BAND (adjustable gastric band) surgery. View project details
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Inflammation: How it affects neurons
The properties of neurons are dramatically changed by inflammation, an effect that long outlasts the inflammation itself. View project details
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Intelligent prediction of mutation effects
| Florey Neuroscience Institutes |
Given a mutation, predict a priori its effect such as protein misfolding and missplicing. The effect of a mutation depends on where it occurs, which could be in an exon (in which case the effect depends on the conservation of the affected residues or whether the mutation is a frameshift), or in a splice site of an intron, elsewhere in an intron, or in a promoter sequence, etc. View project details
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Intelligent prediction of mutation effects
| Florey Neuroscience Institutes |
Given a mutation, predict a priori its effect such as protein misfolding and missplicing. View project details
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