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Behavioural and anatomical characterisation of the effects of unique human-derived amyloid beta (A&beta) species in mouse brain.
| Mental Health Research Institute |
Supervisor(s) - Dr. Paul Adlard, Dr. David Finkelstein, Dr. Robert Cherny, Professor Ashley Bush
email:padlard@mhri.edu.au; dfinkelstein@mhri.edu.au; rcherny@mhri.edu.au; abush@mhri.edu.au
The Oxidation Disorders (Neuropathology) laboratory at MHRI is dedicated to understanding the causes of Alzheimer’s disease (AD), Parkinson’s disease (PD) and other age-related neurodegenerative diseases. The major themes of projects running in the laboratory are: 1) . Oxidative stress in neurological disorders. 2) The molecular and cellular basis of neurotoxicity associated with the deposition of aggregating proteins in the neurodegenerative disorders including AD, PD, Motor Neurone and Huntington’s diseases. 3). Advancing basic understanding of the interactions between cellular proteins and biologically important metals
 View project details
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Chronic degenerative models of Parkinson’s disease.
| Mental Health Research Institute |
Supervisor(s) - Dr. David Finkelstein, Dr. Robert Cherny, Professor Ashley Bush email: dfinkelstein@mhri.edu.au; rcherny@mhri.edu.au; abush@mhri.edu.auLaboratory Overview: The Oxidation Disorders (Neuropathology) laboratory at MHRI is dedicated to understanding the causes of Alzheimer’s disease (AD), Parkinson’s disease (PD) and other age-related neurodegenerative diseases. The major themes of projects running in the laboratory are: 1) . Oxidative stress in neurological disorders. 2) The molecular and cellular basis of neurotoxicity associated with the deposition of aggregating proteins in the neurodegenerative disorders including AD, PD, Motor Neurone and Huntington’s diseases. 3). Advancing basic understanding of the interactions between cellular proteins and biologically important metals View project details
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Corticotropin releasing factor (CRF) & alcohol-seeking
| Florey Neuroscience Institutes |
Alcohol is one of the most widely used psychoactive drugs in the world however its consumption is often associated with considerable social, medical, and financial costs. Approximately 5% of the total annual mortality, and at least $7.5 billion dollars annually is attributed to alcohol and alcohol related problems in Australia alone. At the extreme end of alcohol use is alcohol dependence; a disorder characterised by an unmanageable and chronic compulsion to seek out and consume the drug. Ultimately, this compulsive pattern can lead to significant psychosocial dysfunction for the individual and can also affect family, friends and the wider community (Mathers et al., 1999). Given this tremendous impact, our overall aim is to further elucidate the precise mechanisms that drive the motivation to use alcohol and other drugs. Such information is clearly necessary for the improved targeting of therapeutics to assist in the overall management of patients presenting with substance abuse disorders. View project details
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Free Radicals, Stroke and Angiogenesis
| Bernard O'Brien Institute |
Dr Carli Roulston, Dr Caroline Taylor, Professor Greg Dusting A research student undertaking this project would have the opportunity to gain experience in more than one experimental technique including: In vivo surgical techniques and stroke in rats, behavioural tests to assess neurological function, immunohistochemistry, chemiluminescence for detection of superoxide, and Real time PCR. Knowledge obtained from this project will help optimise anti-oxidant treatment options for patients recovering from stroke. View project details
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Functional MRI studies in epilepsy
| Florey Neuroscience Institutes |
Supervisor(s) - Prof. Graeme Jackson, Dr. Tony Waites, Dr. David, Abbott, Dr. Fernando Calamante,
Prof. Alan Connelly
Overall the epilepsy research group investigates aspects of human brain function in disease using advanced techniques of image analysis. Since the primary focus of the group is on epilepsy, there are opportunities in research for people originating in many disciplined areas including psychology, information technology, computer science, neuroimaging, clinical and basic science areas. The group is multidisciplinary and linked to clinical therapy so research findings are highly focussed to the effective translation of findings to disease therapy. The proposed projects will involve magnetic resonance imaging (MRI) investigations, which will be performed on the fully-dedicated research scanners at the Brain Research Institute (two 3 Tesla MRI scanners). View project details
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