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Behavioural and anatomical characterisation of the effects of unique human-derived amyloid beta (A&beta) species in mouse brain.
| Mental Health Research Institute |
Supervisor(s) - Dr. Paul Adlard, Dr. David Finkelstein, Dr. Robert Cherny, Professor Ashley Bush
email:padlard@mhri.edu.au; dfinkelstein@mhri.edu.au; rcherny@mhri.edu.au; abush@mhri.edu.au
The Oxidation Disorders (Neuropathology) laboratory at MHRI is dedicated to understanding the causes of Alzheimer’s disease (AD), Parkinson’s disease (PD) and other age-related neurodegenerative diseases. The major themes of projects running in the laboratory are: 1) . Oxidative stress in neurological disorders. 2) The molecular and cellular basis of neurotoxicity associated with the deposition of aggregating proteins in the neurodegenerative disorders including AD, PD, Motor Neurone and Huntington’s diseases. 3). Advancing basic understanding of the interactions between cellular proteins and biologically important metals
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Chronic degenerative models of Parkinson’s disease.
| Mental Health Research Institute |
Supervisor(s) - Dr. David Finkelstein, Dr. Robert Cherny, Professor Ashley Bush email: dfinkelstein@mhri.edu.au; rcherny@mhri.edu.au; abush@mhri.edu.auLaboratory Overview: The Oxidation Disorders (Neuropathology) laboratory at MHRI is dedicated to understanding the causes of Alzheimer’s disease (AD), Parkinson’s disease (PD) and other age-related neurodegenerative diseases. The major themes of projects running in the laboratory are: 1) . Oxidative stress in neurological disorders. 2) The molecular and cellular basis of neurotoxicity associated with the deposition of aggregating proteins in the neurodegenerative disorders including AD, PD, Motor Neurone and Huntington’s diseases. 3). Advancing basic understanding of the interactions between cellular proteins and biologically important metals View project details
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Free Radicals, Stroke and Angiogenesis
| Bernard O'Brien Institute |
Dr Carli Roulston, Dr Caroline Taylor, Professor Greg Dusting A research student undertaking this project would have the opportunity to gain experience in more than one experimental technique including: In vivo surgical techniques and stroke in rats, behavioural tests to assess neurological function, immunohistochemistry, chemiluminescence for detection of superoxide, and Real time PCR. Knowledge obtained from this project will help optimise anti-oxidant treatment options for patients recovering from stroke. View project details
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Gene-environment interactions mediating cellular plasticity in the healthy and diseased cerebral cortex
| Florey Neuroscience Institutes |
Supervisor: A/Prof Anthony Hannan One of our general aims is to gain insight into the way in which the genetic programme regulating maturation and function of the cortex is dynamically moulded by environmental stimuli. In particular, one aspect of our research is focused on understanding gene-environment interactions in disorders involving disruption of normal cortical development, plasticity and/or function, such as those associated with schizophrenia (involving abnormal cortical maturation and plasticity) and Huntington’s disease (involving abnormal cortical/striatal function and plasticity). We use a range of techniques, including molecular biology, protein chemistry, neuroanatomy and mouse behavioural analysis, in an attempt to understand how genes and environment combine to affect specific aspects of brain and behaviour. View project details
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MRI methods and their application to neurosciences: Perfusion MRI
| Florey Neuroscience Institutes |
Supervisors - Prof. Alan Connelly and Dr. Fernando Calamante The MRI Technical Development group at the Brain Research Institute is internationally recognised for the development and implementation of advanced perfusion and diffusion MRI techniques. Our particular group has the advantage that this work is taking place within a world class clinical neuroscience research environment. In addition to the MRI Technical Development group, some of the major research groups in Australia (and indeed the world) in the fields of epilepsy, stroke, and neuropsychology are located within the Florey Neurosciences Institutes, or in closely collaborative institutes. Prospective researchers will assist in the development and implementation of novel magnetic resonance acquisition, processing and display techniques in either diffusion or perfusion MRI, or the application of these methodologies to important neuroscience applications; the particular project will depend on the experience and interest of the candidate. We therefore invite enquiries from students with experience in physics, computer science, image processing, or related subjects, or students with a neuroscience background. View project details
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